How fast does Premix insulin start working?

It usually starts lowering blood sugar within 20 minutes of injection.

When is the peak effect?

Peak effect occurs after about 3 hours.

How long does it last?

The total duration of action is around 12 hours.

Premixed / Biphasic

Premixed insulins combine short- or rapid-acting with intermediate-acting components. Provide both meal and basal coverage in one injection.

Onset

min

Fast

Time until it starts working after injection.

Peak

3 h

When effect is strongest (may be minimal for some long-acting insulins).

Duration

approx

Total time the insulin continues to act.

Activity curve (illustrative)

This stylized curve shows a typical onset, peak, and duration profile for Premix insulins. For education only.

How it works

Premix

Premixed insulins contain a fixed ratio of rapid- or short-acting insulin with intermediate-acting insulin, covering both mealtime and background needs. They typically start working within 15–30 minutes, peak at around 2–4 hours, and last 10–16 hours.

Typical use

Often prescribed to simplify injection schedules. Usually injected twice daily before meals in people who need both mealtime and basal insulin in one shot.

Storage & handling

Refrigerate unopened pens or vials (2–8°C). Roll gently before use to mix contents evenly. In-use pens may be stored at room temperature for up to 28 days.

Frequently asked questions

What is premixed insulin and when is it used?

When should I take a premixed insulin dose relative to meals?

Does premixed insulin replace separate basal and bolus insulins?

What if my meal patterns change (e.g., fasting or festival in India)?

Disclaimer: For educational reference only. Always follow your healthcare provider’s instructions.